- The Tenth Doctor - Doctor Who and assorted spin-offs
- DI Alec Hardy - Broadchurch
- Spitelout - How to Train Your Dragon films and television series
- Barty Crouch Jr. - film Harry Potter and the Goblet of Fire
- Kevin Thompson/Kilgrave - Jessica Jones
- Giacomo Casanova - Casanova
Tennant is also a highly respected Shakespearean actor, having performed the title roles in the critically acclaimed productions of Hamlet and Richard II at the Royal Shakespeare Company, as well as playing Benedick in a production of Much Ado About Nothing alongside his Ducktales and Doctor Who co-star Catherine Tate.